Dual stimuli-responsive polypyrrole nanoparticles for anticancer therapy Rania M. Hathout 1, AbdelKader A. Metwally 1, Sherweit H. El-Ahmady 2, Eman S. Metwally 3, Noha A. Ghonim 3, Salma A. Bayoumy 3, Tarek Erfan 3, Rosaline Ashraf 3, Maha Fadel 4, Abdullah I. El-Kholy 4 and John G. Hardy 5,6

The nanogel was further incorporated with gold nanoparticles (AuNP) to provide simultaneous drug delivery and photothermal therapy (PTT).

Nanoparticles, in situ, self-assembled nanoparticles, nanoprecipitation, stimuli-responsive drug release. ABSTRACT Nanotechnology has become an outgrowing field in novel drug delivery system. It confers several merits over conventional formulations like increased solubility and bioavailability, targeted drug delivery and a decreased dose of the Stimuli-responsive materials, which exhibit changes in one or more properties in response to an external trigger, have gained interest due to their tunability and versatility. Our group has prepared stimuli-responsive materials including hydrogels, peptides, and nanoparticles for drug delivery applications.

Stimuli responsive nanoparticles

Against this backdrop, stimuli-responsive antibiotic-loaded nanoparticles and materials with antimicrobial properties (nanoantibiotics) present the ability to enhance therapeutic efficacy, while also reducing drug resistance and side effects. We developed a stimuli-responsive clustered nanoparticle (iCluster) and justified that its adaptive alterations of physico- chemical properties (e.g. size, zeta potential, and drug release rate) in accordance with the endogenous stimuli of the tumor microenvironment made possible the ultimate overcoming of these barriers, especially the bottleneck of tumor penetration. responsive nanoparticles. 4.

Jan 3, 2020 New types of 2D and 3D stimuli‐responsive materials can be constructed by integrating molecular machines as part of their building blocks.

Apr 11, 2016 Nanomaterials Webinar : Stimuli-Responsive Polymers etc. are considered to be stimuli responsive where the change can be reversible or irreversible. Gold Nanoparticles Webinar: Strange properties and applications. A hurdle to this goal is the inherently unfavorable tumor penetration of nanoparticles due to their relatively large sizes.

reliable linkers · stimuli-responsive. First draft submitted: 1 March 2017; Accepted for publication: 14

These nanoparticles either response to internal stimuli such as Stimuli‐responsive upconversion nanoparticles also utilize the excessive presence of adenosine triphosphate (ATP), riboflavin, and Zn 2+ in tumors. An overview of the design of stimulus‐responsive upconversion nanoparticles that precisely target and respond to tumors via targeting the tumor microenvironment and intracellular signals is provided. The stimuli-responsive nanocarriers are mainly functionalized to delivery, release and activate cargos in specific regions (e.g., tumor microenvironments or intracellular spaces of cancer cells) by responding to internal/external stimuli, e.g., pH, enzymes, etc. [ 18, 19 ], while the ligand-installed nanocarriers are mainly applied to promote the specific internalization between nanocarriers and specific cells, e.g., … Using stimuli responsive core-shell particles to produce responsive colloidosomes from emulsion templates 73. Amihay Freeman (Tel Aviv University) Silver-coated biologically active protein hybrids: Biomedical applications 74. Rahul Jayant (Institut Charles Sadron) Spray mixing - A new approach toward the preparation of plasmid DNA complexes 75.

Solvents. Depending mostly on the ligand molecules bound to their surfaces, nanoparticles exhibit good solubility in 2. Acid/base. It has long been recognized that the colloidal stability of nanoparticles is largely dependent on the NP 3.
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However, the rational design of these “smart” nanoparticles for a selective delivery and controlled release of multidrug combinations in cancer cells to achieve synergistic effects remain challenging.

In an effort to further improve drug release performances, novel dual and multi-stimuli responsive polymeric nanoparticles that respond to a combination of two or more signals such as pH/temperature, pH/redox, pH/magnetic field, temperature/reduction, double pH, pH and diols, temperature/magnetic field, temperature/enzyme, temperature/pH/redox The thermo-responsiveness and singlet oxygen generation of the loaded ICG in DMMA-modified PLL nanoparticles are comparable to those of free ICG under laser irradiation, which induces higher cytotoxicity to cancer cells compared to succinic anhydride (SA)-modified PLL nanoparticles that are not pH-responsive.
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Dec 15, 2016 Many stimulus-responsive MSN-based DDSs have been designed to respond to various internal and external stimuli, such as pH (16), redox

Our group has prepared stimuli-responsive materials including hydrogels, peptides, and nanoparticles for drug delivery applications. Against this backdrop, stimuli-responsive antibiotic-loaded nanoparticles and materials with antimicrobial properties (nanoantibiotics) present the ability to enhance therapeutic efficacy, while also reducing drug resistance and side effects.